解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVE:To investigate 1-year outcomes of a national diabetes prevention program in Finland. RESEARCH DESIGN AND METHODS:Altogether 10,149 individuals at high risk for diabetes were identified with the Finnish Diabetes Risk Score (FINDRISC; scoring ≥15 points), by a history of impaired fasting glucose (IFG) or impai...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-0410
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To compare fenofibric acid (FA) + statin to respective monotherapies on the prevalence of metabolic syndrome and its diagnostic components in patients with mixed dyslipidemia. RESEARCH DESIGN AND METHODS:Post hoc analysis of over 2,000 metabolic syndrome patients administered either FA + low- or moderate-dos...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc10-0357
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To investigate the association between circulating levels of hepatocyte growth factor (HGF), a mesenchymal-derived pleiotrophic factor that is elevated in obesity, and the prevalence of type 2 diabetes. RESEARCH DESIGN AND METHODS:A cross-sectional analysis among 892 postmenopausal women within the Women's H...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-0710
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:Diabetes is a predictor of both coronary artery disease (CAD) and heart failure. It is unknown to what extent the association between diabetes and heart failure is influenced by other risk factors for heart failure. RESEARCH DESIGN AND METHODS:We evaluated the association of diabetes and A1C with incident he...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc10-0286
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:Previous reviews of the effect of oral antidiabetic (OAD) agents on A1C levels summarized studies with varying designs and methodological approaches. Using predetermined methodological criteria, we evaluated the effect of OAD agents on A1C levels. RESEARCH DESIGN AND METHODS:The Excerpta Medica (EMBASE), the...
journal_title:Diabetes care
pub_type: 杂志文章,meta分析,评审
doi:10.2337/dc09-1727
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes. RESEARCH DESIGN AND METHODS:We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validate...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2302
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:Serine-threonine kinase STK11 catalyzes the AMP-activated protein kinase complex. We tested the hypothesis that a gene variant in STK11 contributes to variation in insulin sensitivity and metformin efficacy. RESEARCH DESIGN AND METHODS:We studied the effects of a single nucleotide polymorphism (SNP) (rs81116...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1750
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:Growth deferentiation factor-15 (GDF-15) is involved in inflammation and apoptosis. Expression is induced in the heart in response to ischemia and in atherosclerotic plaques. The aim of this study was to investigate GDF-15 levels in relation to all-cause mortality, cardiovascular mortality and morbidity, decl...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2174
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance. RESEARCH DESIGN AND METHODS:In 1,176 South Asian, Chinese, Aboriginal, and European Canadians, fasting blood s...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1392
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:Many of the metabolic benefits of Roux-en-Y gastric bypass (RYGB) occur before weight loss. In this study we investigated the influence of caloric restriction on the improvements in the metabolic responses that occur within the 1st week after RYGB. RESEARCH METHODS AND DESIGN: A mixed meal was administered to...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2107
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To assess the additional effect of sudden visceral fat reduction by omentectomy on metabolic syndrome, acute-phase reactants, and inflammatory mediators in patients with grade III obesity (G-III O) undergoing laparoscopic Roux-en-Y gastric bypass (LRYGB). RESEARCH DESIGN AND METHODS:Twenty-two patients were ...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc09-1833
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To evaluate whether use of oral hypoglycemic agents is associated with an altered breast cancer risk in women. RESEARCH DESIGN AND METHODS:Using the U.K.-based General Practice Research Database, we conducted a nested case-control analysis among 22,621 female users of oral antidiabetes drugs with type 2 diab...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1791
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes. RESEARCH DESIGN AND METHODS:Serum 25(OH)D was determined using a chemiluminescence immunoassay. Insulin s...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2321
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Whereas single assessments of cardiorespiratory fitness have been shown to predict lower incidence of type 2 diabetes, there are no data on long-term trends in fitness and risk. We investigated the relationship between long-term trends in fitness and the incidence of type 2 diabetes. RESEARCH DESIGN AND METH...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1654
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Diabetic patients have a high prevalence of coronary artery disease (CAD), but timely diagnosis of CAD remains challenging. We assessed the ability of coronary computed tomography angiography (CCTA) to detect CAD in diabetic patients and to predict subsequent cardiac events. RESEARCH DESIGN AND METHODS:We an...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/dc09-2104
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Age at onset of type 1 diabetes influences the risk of microvascular complications. However, the long-term risk of proliferative retinopathy within the wide spectrum of age at onset of type 1 diabetes is less well known. RESEARCH DESIGN AND METHODS:A sample of 1,117 consecutively recruited patients was drawn...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2278
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the utility of GAD antibodies (GADAs) and islet antigen-2 antibodies (IA-2As) in prediction of type 1 diabetes over 27 years in the general population and to assess the 6-year rates of seroconversion. RESEARCH DESIGN AND METHODS:A total of 3,475 nondiabetic subjects aged 3-18 years were sampled i...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1040
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To assess the long-term cost-effectiveness of aspirin use among adults aged >or=40 years with newly diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS:We used a validated cost-effectiveness model of type 2 diabetes to assess the lifetime health and cost consequences of use or nonuse of aspirin. The model...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1888
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:In view of the previously described anti-inflammatory effects of insulin, we investigated the potential suppressive effect of insulin on plasma concentrations and expression of the chemokines, monocyte chemoattractant protein-1 (MCP-1) and regulated on activation normal T-cell expressed and secreted (RANTES) ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-2193
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:Nonalcoholic fatty liver disease is highly prevalent in obese and type 2 diabetic individuals and is strongly associated with dyslipidemia and inflammation. Weight loss and/or pharmacotherapy are commonly used to correct these abnormalities. RESEARCH DESIGN AND METHODS:We performed a 16-week intervention tri...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc09-1765
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To investigate relationships between baseline factors and treatment-associated efficacy changes in type 2 diabetes. RESEARCH DESIGN:AND METHODS Multivariable analyses of treatment response in 1,229 type 2 diabetic patients with hypercholesterolemia who received ezetimibe/simvastatin or atorvastatin in a rand...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc09-1762
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:Gestational diabetes mellitus (GDM) may cause obesity in the offspring. The objective was to assess the effect of treatment for mild GDM on the BMI of 4- to 5-year-old children. RESEARCH DESIGN AND METHODS:Participants were 199 mothers who participated in a randomized controlled trial of the treatment of mil...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc09-1810
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To determine whether evidence-based socioculturally adapted collaborative depression care improves receipt of depression care and depression and diabetes outcomes in low-income Hispanic subjects. RESEARCH DESIGN AND METHODS:This was a randomized controlled trial of 387 diabetic patients (96.5% Hispanic) with...
journal_title:Diabetes care
pub_type: 杂志文章,随机对照试验
doi:10.2337/dc09-1711
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To determine if baseline subgroups in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial can be identified for whom intensive compared with standard glycemia treatment had different effects on all-cause mortality. RESEARCH DESIGN AND METHODS:Exploratory post hoc intention-to-treat compariso...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc09-1471
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Arterial stiffness occurs early in the atherosclerotic process; however, few data are available concerning risk factors for arterial stiffness in youth with diabetes. We identified factors associated with arterial stiffness in youth with diabetes and assessed the effects of these factors on the relationship b...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0747
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To evaluate to what extent the association between family history of diabetes and risk of type 2 diabetes can be explained by excess adiposity and lifestyle risk factors. RESEARCH DESIGN AND METHODS:We analyzed data from 73,227 women who participated in the Nurses' Health Study cohort. A family history of di...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1586
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Newer medications offer more options for glycemic control in type 2 diabetes. However, they come at considerable costs. We undertook a health economic analysis to better understand the value of adding two newer medications (exenatide and sitagliptin) as second-line therapy to glycemic control strategies for p...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1488
更新日期:2010-04-01 00:00:00
abstract::OBJECTIVE The American Diabetes Association advocates insulin regimens for youth with type 1 diabetes that involve adjusting insulin dose based on carbohydrate intake and blood glucose level. Implementing these regimens requires knowledge about carbohydrate content of foods and subsequent calculations of insulin dose,...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0390
更新日期:2010-03-01 00:00:00
abstract::OBJECTIVE To examine the efficacy and safety of rimonabant, a selective cannabinoid receptor type-1 antagonist, in patients with type 2 diabetes receiving insulin monotherapy. RESEARCH DESIGN AND METHODS Patients (n = 368; A1C > or =7%) were randomized to 20 mg/day rimonabant or placebo in this 48-week, double-blind, ...
journal_title:Diabetes care
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2337/dc09-0455
更新日期:2010-03-01 00:00:00
abstract::OBJECTIVE Mortality rates have declined substantially over the past decades in the general population, but the situation among diabetic subjects is less clear. The aim of this study was to analyze mortality trends in diabetic and nondiabetic subjects during 1972-2004. RESEARCH DESIGN AND METHODS Since 1972, all patien...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0680
更新日期:2010-03-01 00:00:00
abstract::OBJECTIVE Using the clamp technique, youths with a clinical diagnosis of type 2 diabetes (CDx-type 2 diabetes) and positive pancreatic autoantibodies (Ab(+)) were shown to have severe impairment in insulin secretion and less insulin resistance than their peers with negative antibodies (Ab(-)). In this study, we invest...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-0305
更新日期:2010-03-01 00:00:00
abstract::OBJECTIVE To determine if glucose and C-peptide values obtained as part of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study could be used to estimate insulin sensitivity during late pregnancy. RESEARCH DESIGN AND METHODS A total of 78 women enrolled in the HAPO study were recruited for this ancillary study...
journal_title:Diabetes care
pub_type: 临床试验,杂志文章
doi:10.2337/dc09-1463
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:It is believed that disruption of vulnerable atherosclerotic plaque and subsequent thrombus formation play critical roles in the pathogenesis of cerebral infarction. We simultaneously determined four relatively common genetic variants related to plaque rupture or subsequent local thrombus formation and evalua...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1518
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. RESEARCH DESIGN AND METHODS:A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and be...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1342
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To describe the clinical experience and the pharmacokinetics of U-500 regular insulin in severely insulin-resistant obese type 2 diabetic patients. RESEARCH DESIGN AND METHODS:Patients requiring >200 units of insulin with A1C levels >8.0% were switched to U-500 regular insulin. For the pharmacokinetic study,...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1490
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To study the association between microalbuminuria and development of preeclampsia and preterm delivery in pregnant women with type 1 diabetes. RESEARCH DESIGN AND METHODS:This was a population-based prospective study in 846 normoalbuminuric or microalbuminuric women with type 1 diabetes without antihypertens...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1219
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Dietary recommendations are focused mainly on relative dietary fat and carbohydrate content in relation to diabetes risk. Meanwhile, high-protein diets may contribute to disturbance of glucose metabolism, but evidence from prospective studies is scarce. We examined the association among dietary total, vegetab...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1321
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To compare A1C and fasting glucose for the diagnosis of diabetes among U.S. adults. RESEARCH DESIGN AND METHODS:This study included 6,890 adults (> or =20 years of age) from the 1999-2006 National Health and Nutrition Examination Survey without a self-reported history of diabetes who had fasted > or =9 h. A1...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1227
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To describe the impact of abdominal obesity and hepatic insulin resistance on phase-specific glycemic responses in older women. RESEARCH DESIGN AND METHODS:We studied 23 healthy older women (60-88 years old). Abdominal obesity was defined by an abdominal circumference > or =95 cm. Plasma glucose and insulin ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1365
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To compare recent U.S. and U.K. guidelines on gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS:The guidelines from the American Diabetes Association, the American College of Obstetricians and Gynecologists, and the National Institute for Health and Clinical Excellence (NICE) in the U.K. were ...
journal_title:Diabetes care
pub_type: 杂志文章
doi:10.2337/dc09-1376
更新日期:2010-01-01 00:00:00